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Role of lncRNAs in pathophysiology of obesity
Vikram Krishnappa Shettigar1, Venkata Naga Srikanth Garikipati1
1Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Abstract:
Obesity is a growing problem worldwide, with its pathophysiology being keenly explored. Previously, the noncoding transcriptome was considered transcriptional noise with no functional relevance. However, emerging evidence suggests a critical role for non-coding RNAs, especially long non-coding RNAs (lncRNAs), in obesity. Several lncRNAs have been identified that facilitate the development of obesity (such as LINK-A) or resist obesity (such as lnc266). These findings emphasize the importance of the study of lncRNA, which could be the master regulators of disease progression and the key to the development of novel therapeutics.
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