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The relationship between sarcopenic obesity and cognitive functionality among inpatients with stable schizophrenia
Yan Guo1, Jianfei Wu2, Xiuping Lei1
1Department of Psychiatry, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, Sichuan, China.
Plos One
|August 18, 2025
Summary
Sarcopenic obesity (SO) is linked to cognitive decline in schizophrenia patients. The modified SOESPEN-M criteria identified SO associated with lower cognitive scores, particularly in males with schizophrenia.
Area of Science:
- Gerontology
- Neuroscience
- Psychiatry
Background:
- Schizophrenia patients have a higher risk of sarcopenic obesity (SO) due to metabolic issues and inactivity.
- The link between SO and cognitive decline in schizophrenia needs further investigation.
Purpose of the Study:
- To compare diagnostic concordance between SOESPEN and SOESPEN-M criteria for SO.
- To assess the association of SO with cognitive function in stable schizophrenia inpatients.
Main Methods:
- 228 stable schizophrenia inpatients were assessed for SO using SOESPEN and SOESPEN-M criteria.
- Cognitive function was measured using the Montreal Cognitive Assessment-Chinese version (MoCA-C).
- Multivariate regression analyzed the relationship between SO and MoCA-C scores.
Main Results:
- SO prevalence was 17.1% by both criteria, with moderate agreement.
- SO groups consistently showed lower MoCA-C scores compared to non-SO groups.
- SO defined by SOESPEN-M was independently linked to lower MoCA-C scores in males.
Conclusions:
- The SOESPEN-M criteria effectively identify SO associated with cognitive impairment in male schizophrenia patients.
- SO is a significant factor impacting cognitive function in this population.
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