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Risks of cataract surgery in solid and hematologic cancer survivors
Hyunjean Jung1, Sunyeup Kim2, Byoung Hyuck Kim3,4
1Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Yonseiro 50, Seodaemungu, Seoul, Korea.
Scientific Reports
|August 18, 2025
Summary
Cancer survivors generally do not face increased cataract surgery risk. However, hematologic cancer patients show a significantly higher risk, especially 2-5 years post-treatment, requiring long-term eye care.
Area of Science:
- Ophthalmology
- Oncology
- Epidemiology
Background:
- Cancer survivors may experience long-term health complications.
- Cataract surgery is a common procedure, and its risk factors in specific populations warrant investigation.
Purpose of the Study:
- To compare the risk of cataract surgery in cancer survivors versus non-cancer controls.
- To identify specific cancer types and patient factors associated with increased cataract surgery risk.
Main Methods:
- Nationwide retrospective cohort study using the National Health Insurance Service database (4.5 million adults).
- Propensity score (PS)-matching at a 3:1 ratio to create comparable cancer (55,968) and control (167,766) groups.
- Survival analysis over up to 10 years to assess cataract surgery incidence.
Main Results:
- Overall cancer survivors showed no significant difference in cataract surgery risk compared to controls.
- Solid cancer survivors had similar risk, but hematologic cancer survivors exhibited a significantly increased risk (HR 1.81 at year 2).
- Factors increasing risk in hematologic cancer survivors included advanced age, leukemia, bone marrow transplantation, and prolonged steroid use.
Conclusions:
- Hematologic cancer survivors face an elevated risk of requiring cataract surgery.
- Long-term ophthalmologic surveillance is crucial for hematologic cancer survivors.
- Understanding specific risk factors can guide preventative eye care strategies.
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