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[Electrically activated blood].

K M Sedlarik, I Mäder, A Ungrova

    Zeitschrift Fur Experimentelle Chirurgie, Transplantation, Und Kunstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Fur Chirurgie Der DDR
    |January 1, 1985
    PubMed
    Summary
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    Electrically activated blood (EAB) can simulate thrombosis experimentally. An iodinated X-ray contrast medium effectively prevents EAB-induced arterial thrombosis, offering a potential therapeutic strategy.

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Vascular Biology

    Context:

    • Electrically activated blood (EAB) is an endogenous thrombogenic substance.
    • Thrombosis can be simulated experimentally by occluding a vessel with EAB.
    • EAB demonstrates resistance to endogenous fibrinolysis compared to spontaneously coagulated blood.

    Purpose:

    • To investigate the thrombogenic properties of electrically activated blood (EAB).
    • To evaluate the efficacy of an iodinated X-ray contrast medium in preventing EAB-induced thrombosis.

    Summary:

    • Direct current electrically activated blood (EAB) forms an agglutinative thrombus, permanently occluding vessels.
    • EAB exhibits greater resistance to fibrinolysis than spontaneously coagulated blood, even with in vitro thrombus addition.

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  • An iodinated X-ray contrast medium (Visotrast 370) was found to prevent arterial thrombosis induced by EAB.

    • Impact:

    • This research provides a model for experimental thrombosis simulation.
    • Identifies a potential preventative agent against EAB-induced arterial thrombosis.
    • Contributes to understanding blood activation, coagulation, and thrombosis mechanisms.