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Recurrent Periocular Nodules: Lymphomatoid Papulosis in an Uncommon Anatomic Site
Alexa Lum1, Jessica Colon2, Kristi Hawley3
1Dermatology, Michigan State University College of Osteopathic Medicine, East Lansing, USA.
Cureus
|August 19, 2025
Summary
Lymphomatoid papulosis (LyP) is a rare skin disorder of CD30-positive T-cells. Accurate diagnosis requires integrating clinical presentation with histopathology, especially in unusual locations.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Lymphomatoid papulosis (LyP) is a rare cutaneous lymphoproliferative disorder characterized by CD30-positive T-cell dysregulation.
- LyP presents as papulonodular skin lesions that typically resolve spontaneously but can recur.
Observation:
- A case report details a 44-year-old male with recurrent, painful nodules under the right eye, initially misdiagnosed.
- Despite various treatments, the patient experienced persistent, localized flares.
- Histopathology revealed a CD30-positive atypical lymphoid infiltrate.
Findings:
- The diagnosis of LyP was confirmed by combining clinical presentation with characteristic histopathologic findings.
- This case underscores the importance of histopathology in diagnosing LyP, particularly in atypical presentations.
Implications:
- Accurate diagnosis of LyP is crucial due to its resemblance to other lymphoproliferative diseases.
- Regular monitoring by a hematologist/oncologist is recommended for patients with LyP to detect potential progression to malignant lymphoma.
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