Wearable and implantable microfluidic technologies for future digital therapeutics.

Area of Science:

• Biomedical Engineering
• Microfluidics
• Digital Therapeutics

Background:

• Microfluidic technology, initially for lab-on-a-chip, now extends to wearable and implantable biomedical systems.
• These systems enable precise fluid handling for biosensing, drug delivery, and closed-loop therapeutics.
• Integration with the human body requires adaptable and versatile microfluidic platforms.

Purpose of the Study:

• To provide a comprehensive review of recent advancements in microfluidic platforms for human body integration.
• To highlight key design strategies for wearable and implantable microfluidic systems.
• To discuss technological directions for future digital therapeutics.

Main Methods:

• Review of recent literature on microfluidic platforms for biomedical applications.
• Analysis of design strategies including soft electronics, wireless communication, and multimodal sensing.
• Discussion of technological advancements for digital therapeutics.

Main Results:

• Microfluidic integration with soft electronics, wireless communication, and multimodal sensing enhances adaptability.
• Stretchability, multimodal integration, and AI-driven data processing are critical for advanced digital therapeutics.
• Current microfluidic systems are evolving into intelligent, autonomous platforms.

Conclusions:

• Microfluidic systems are crucial for personalized, responsive, and integrated digital healthcare.
• Advancements in microfluidics are transforming healthcare through intelligent and autonomous platforms.
• The future of digital therapeutics relies on sophisticated, body-integrated microfluidic technologies.