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Visible-Light-Driven Iron-Catalyzed Atom Transfer Radical Addition of CH2Br2 to Alkenes: Facile Access to 1,3-Dibromo
Ning Yan1, Yi Wang1, Ming Bao1
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116023, China.
Abstract:
An efficient visible-light-mediated iron-catalyzed atom transfer radical addition (ATRA) reaction between CH2Br2 and various alkenes has been developed. This transformation provides direct access to synthetically valuable 1,3-dibromo compounds with excellent atom economy under mild reaction conditions. The protocol demonstrates remarkable versatility, exhibiting broad substrate scope and excellent functional group compatibility. Notably, the obtained 1,3-dibromo products function as highly versatile synthetic building blocks. Through rationally designed one-pot multistep transformations, these intermediates can be conveniently converted into structurally diverse derivatives, including oxetanes and allyl bromides, directly from terminal alkenes.
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