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Related Experiment Video

Updated: Sep 10, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Kidney Dysfunction Following Gestational Diabetes Mellitus.

Mairéad Hamill1, Cristina Gomez Fernandez2,3, Rea Mitsigiorgi2

  • 1School of Life Course and Population Sciences, King's College London, London, United Kingdom.

Clinical Journal of the American Society of Nephrology : CJASN
|August 19, 2025
PubMed
Summary

Postpartum screening found kidney dysfunction in 12% of women with previous gestational diabetes mellitus (GDM). Most women had cardiovascular risk factors, highlighting the need for early intervention to prevent future disease.

Keywords:
CKD nondialysiscardiovascular diseasediabetes mellitusethnicityhypertensionmicroalbuminuriarenal progressionwomen's health

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Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Gestational diabetes mellitus (GDM) increases maternal risk for type 2 diabetes and cardiovascular issues like chronic kidney disease (CKD).
  • Early postpartum detection of CKD and cardiovascular risk factors in GDM patients is crucial for timely intervention.
  • Postpartum clinics offer a vital opportunity to address these risks, particularly in marginalized populations.

Purpose of the Study:

  • To investigate the prevalence of CKD features and cardiovascular disease risk factors postpartum in women with a history of GDM.
  • To assess the utility of postpartum clinics for early disease burden reduction in GDM patients.

Main Methods:

  • A cohort of women with GDM attending a UK tertiary maternity unit were invited to a 5-month postpartum visit.
  • Data collected included maternal demographics, medical history, pregnancy outcomes, and assessments of kidney dysfunction, dysglycemia, hypertension, adiposity, and dyslipidemia.
  • Urine albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) were used to assess kidney function.

Main Results:

  • 12% of women exhibited kidney dysfunction (elevated UACR), while 1% had reduced eGFR.
  • Only 9% of women with kidney dysfunction met criteria for type 2 diabetes.
  • 75% of women presented with at least one cardiometabolic risk factor (kidney dysfunction, dyslipidemia, dysglycemia, hypertension).

Conclusions:

  • Microalbuminuria is common in women with prior GDM at 5 months postpartum.
  • While most do not meet type 2 diabetes criteria, a significant majority have cardiovascular risk factors.
  • Early postpartum assessment is essential for identifying and managing cardiometabolic risks in women with GDM.