Related Experiment Video
Updated: Sep 10, 2025
08:41
Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
Published on: July 29, 2017
14.1K
Biphasic mammary tumor in a cat: Case report
Adina-Mihaela Pîrvu1, Elvira Gagniuc2, Cătălin Micșa1
1University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, 050097, Splaiul Independentei No. 105, 5(th) district, Bucharest, Romania.
Research in Veterinary Science
|August 19, 2025
Summary
Biphasic tumors are rare feline mammary neoplasms. This case study details a rare carcinosarcoma in a domestic cat, emphasizing the need for its inclusion in differential diagnoses for feline mammary tumors.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunohistochemistry
Background:
- Feline mammary tumors (FMT) represent a significant health concern in domestic cats.
- Biphasic tumors (BT), characterized by dual neoplastic cell types, are exceptionally uncommon among FMTs.
Observation:
- This study presents a detailed histological and immunohistochemical analysis of a biphasic mammary tumor in a 7-year-old Domestic Shorthair cat.
- Histopathology revealed distinct malignant epithelial and mesenchymal cell populations.
- Immunohistochemistry confirmed epithelial differentiation (cytokeratins) and mesenchymal markers (vimentin, α-SMA) in the respective tumor components.
Findings:
- The epithelial component showed high proliferation (Ki-67 index: 88.8%), while the mesenchymal component had a lower index (22.9%).
- The tumor was diagnosed as a carcinosarcoma based on integrated histopathological and immunohistochemical evidence.
- Specific markers like cytokeratins, vimentin, α-SMA, and calponin aided in differentiating the biphasic nature.
Implications:
- This case underscores the importance of considering biphasic mammary tumors, specifically carcinosarcomas, in the diagnostic workup of feline mammary neoplasms.
- Accurate diagnosis through comprehensive histological and immunohistochemical evaluation is crucial for understanding and managing these rare feline cancers.
