A case report of dermatofibrosarcoma protuberans with osteolytic

Area of Science:

• Oncology
• Orthopedic Oncology
• Pathology

Background:

• Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma with low metastatic potential.
• Local recurrence is common, but distant metastasis, particularly to bone, is exceptionally rare.

Purpose of the Study:

• To report a rare case of DFSP with solitary bone metastasis to the humerus.
• To emphasize the importance of comprehensive diagnostic approaches for rare metastatic presentations.

Main Methods:

• A 42-year-old male with a history of DFSP presented with humerus bone destruction and a soft tissue mass.
• Imaging and aspiration biopsy confirmed metastatic DFSP.
• Palliative treatment was initiated, with follow-up monitoring.

Main Results:

• The humeral lesion initially responded to palliative treatment but later progressed.
• Multiple new bone metastases were identified on follow-up.
• This case highlights the unusual metastatic behavior of DFSP.

Conclusions:

• Metastasis of DFSP, especially to bone, is rare and requires integrated diagnostic strategies.
• Comprehensive evaluation including medical history, imaging, immunohistochemistry, and molecular pathology is essential.
• Prompt core biopsy and thorough patient history are vital for accurate diagnosis and optimal treatment planning for bone pain presentations.