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Percutaneous Vertebroplasty Using GeneX® in Osteoporotic Vertebral Compression Fractures: A Case Report
Taibang Chen1, Lei Cui1, Di Du1
1Department of Orthopaedic Surgery of 920th Hospital of Joint Logistics Support Force, Kunming, People's Republic of China.
GeneX shows risks in percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Complications like bone cement implantation syndrome occurred, necessitating further safety trials before widespread use.
Area of Science:
- Orthopedic surgery
- Biomaterials science
- Neurosurgery
Background:
- GeneX promotes bone formation through molecular adsorption and aggregation.
- It is utilized in bone defect reconstruction and percutaneous vertebroplasty.
Observation:
- A prospective study evaluated GeneX in percutaneous vertebroplasty for osteoporotic vertebral compression fractures.
- Four of seven patients experienced material leaks, with one case causing severe neurological deficits (bone cement implantation syndrome).
Findings:
- GeneX is not recommended for percutaneous vertebroplasty in OVCF due to its physicochemical properties.
- Long-term safety and efficacy require further validation via Phase II clinical trials.
Implications:
- Sophisticated surgical techniques do not mitigate GeneX risks in percutaneous vertebroplasty.
- Lumbar cistern drainage may improve neurological deficits from GeneX implantation syndrome.
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