Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical Characterization of Slide Tracheoplasty Versus End-to-End Anastomosis in Ex Vivo Porcine Tracheas.

The Laryngoscope·2026
Same author

Recovery-Targeted Supplemental Oxygen Enhances Performance and Attenuates Perceived Fatigue During Subsequent High-Intensity Swimming.

Sports (Basel, Switzerland)·2026
Same author

Evaluating the Efficacy of Nebulized Ciprofloxacin-Dexamethasone Using a Novel Model of Airway Stenosis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Differential Balance Enhancements Associated with Conventional Balance Training and Portable Slackline Board Training: A Randomized Controlled Trial.

Sports (Basel, Switzerland)·2025
Same author

Factors Associated With Operative Time, Operating Room Idle Time, and Return to the Operating Room for Hip Arthroscopy: An Analysis of 740 Hip Arthroscopies for Femoroacetabular Impingement.

Orthopaedic journal of sports medicine·2025
Same author

Epidemiology of MUCL Repair and Reconstruction: A 5-Year Study in New York State.

Orthopaedic journal of sports medicine·2025

Related Experiment Video

Updated: Sep 8, 2025

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts
06:27

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts

Published on: May 16, 2020

3.5K

Clinical Status of Exosomes: A Review.

Jonathan Sgaglione1, Eric V Neufeld2, Pooja Swami3

  • 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.

HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery
|August 20, 2025
PubMed
Summary

Exosomes, nano-sized vesicles from stem cells, offer therapeutic potential for tissue repair and managing various disorders. They provide regenerative effects with fewer risks than cell therapies, aiding intercellular communication.

Keywords:
extracellular vesiclemesenchymal stem cellsregenerative medicinestem cells

More Related Videos

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues
05:27

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Published on: September 20, 2024

851
Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
11:15

Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy

Published on: January 4, 2018

39.7K

Related Experiment Videos

Last Updated: Sep 8, 2025

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts
06:27

Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts

Published on: May 16, 2020

3.5K
Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues
05:27

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Published on: September 20, 2024

851
Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy
11:15

Sample Preparation and Imaging of Exosomes by Transmission Electron Microscopy

Published on: January 4, 2018

39.7K

Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Exosomes are nano-sized vesicles secreted by cells, including mesenchymal stem cells, acting as key mediators of intercellular communication.
  • They transport bioactive molecules like proteins, lipids, and nucleic acids, influencing cellular processes such as immune response and tissue repair.
  • Compared to cell therapies, exosomes offer reduced risks like toxicity and immunogenicity, presenting a safer alternative for therapeutic applications.

Purpose of the Study:

  • To review current techniques for exosome isolation, modification, characterization, and storage.
  • To discuss challenges and innovative strategies for the clinical translation of exosome-based therapies.
  • To examine the potential of exosomes in managing degenerative and non-degenerative musculoskeletal and neurological conditions.

Main Methods:

  • Literature review of isolation, modification, characterization, and storage techniques for exosomes.
  • Analysis of engineering strategies to enhance exosome targeting and therapeutic efficacy.
  • Examination of preclinical and clinical evidence for exosome applications in various disorders.

Main Results:

  • Exosomes demonstrate anti-inflammatory, immunosuppressive, and regenerative properties.
  • Various methods exist for exosome isolation and characterization, with ongoing advancements in engineering for improved targeting.
  • Preliminary evidence supports exosome potential in treating osteoarthritis, disc degeneration, osteoporosis, nerve injury, and trauma.

Conclusions:

  • Exosomes represent a promising cell-free therapeutic approach with significant potential in regenerative medicine.
  • Overcoming challenges in clinical translation through innovative engineering is crucial for realizing exosome therapy benefits.
  • Further research is warranted to fully elucidate the therapeutic applications of exosomes in a range of degenerative and non-degenerative conditions.