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Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor

Zhe Li1, Carsten Alt1, Kobina Dufu1

  • 1Pfizer Inc, South San Francisco, California 94080, United States.

ACS Medicinal Chemistry Letters
|August 20, 2025
PubMed
Abstract

Keywords:
Schiff-base formationcovalent sickle hemoglobin modulatorhemoglobin oxygen affinityosivelotorred blood cell partitioningsickle cell disease

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