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Related Experiment Video

Updated: Sep 8, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653

J Matthijs Biesbroek^1,2, Floor A S de Kort¹, Devasuda Anblagan³

¹Department of Neurology, University Medical Center Utrecht Brain Center, the Netherlands (J.M.B., F.A.S.d.K., G.J.B.).

|August 20, 2025

Summary

This summary is machine-generated.

Vascular risk factors like hypertension are linked to white matter hyperintensities (WMH) in specific brain locations. While hypertension shows a distinct WMH pattern, other factors primarily increase overall WMH volume.

Keywords:

arteriolosclerosis cerebral amyloid angiopathy cerebral small vessel diseases hypertension vascular diseases

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Published on: September 25, 2019

Area of Science:

Neurology
Vascular Medicine
Neuroimaging

Background:

White matter hyperintensities (WMH) are common in older adults and linked to vascular risk factors.
Hypertension is a known risk factor for WMH, but specific patterns across different risk factors are not well understood.

Purpose of the Study:

To investigate the association between specific vascular risk factors and WMH locations in community-dwelling individuals.
To determine if distinct vascular risk factors exhibit unique WMH distribution patterns.

Main Methods:

Pooled data from 16 population-based cohorts (15,653 individuals) via the Meta VCI Map Consortium.
Quantified WMH volumes in 50 white matter regions and associations with 6 vascular risk factors using linear mixed models.
Analyses adjusted for age, sex, study site, and total WMH volume.

Main Results:

Hypertension, smoking, diabetes, and history of vascular disease were associated with higher total WMH volume.
Hypertension showed significant associations with WMH in 10 specific white matter regions.
Smoking, diabetes, and obesity were associated with WMH in one region each after controlling for total WMH volume.

Conclusions:

Hypertension demonstrates a signature pattern of white matter hyperintensities.
Associations of other vascular risk factors with regional WMH appear to be driven by a general increase in WMH volume rather than region-specific effects.