Related Experiment Video

Updated: Sep 10, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

903

Atrioventricular Coupling Index: A Novel Approach to Risk-Stratification for Major Adverse Cardiovascular Events in

Jing-Ping Wu1, Yun Zhao1, Xing-Yu Gu1

  • 1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Journal of Magnetic Resonance Imaging : JMRI
|August 20, 2025
PubMed

Insights

Left and right atrioventricular coupling indices (LACI and RACI) independently predict major adverse cardiac events in acute myocardial infarction (AMI) patients, improving risk stratification beyond traditional factors.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Prognostics

Background:

  • The prognostic value of the left atrioventricular coupling index (LACI) in acute myocardial infarction (AMI) is established.
  • The prognostic role of the right atrioventricular coupling index (RACI) in AMI remains less understood.

Purpose of the Study:

  • To investigate the prognostic significance of both LACI and RACI in patients following AMI.
  • To determine if these indices offer incremental prognostic value beyond conventional risk factors.

Main Methods:

  • A retrospective analysis of 1083 ST-elevation AMI patients who underwent cardiac MRI within 7 days of percutaneous coronary intervention.
  • LACI and RACI were calculated from MRI-derived indexed atrial and ventricular end-diastolic volumes.
  • Major adverse cardiac events (MACE), including all-cause death, reinfarction, and heart failure hospitalization, were tracked over a median of 38 months.

Main Results:

  • Both LACI and RACI were independently associated with MACE in AMI patients.
  • The addition of LACI and/or RACI significantly improved the prognostic model's predictive power (Harrell's C index increased from 0.679 to 0.762).
  • In patients with right ventricular myocardial infarction (RVMI), RACI demonstrated superior prognostic performance compared to LACI.

Conclusions:

  • LACI and RACI are independent predictors of MACE in AMI.
  • These indices provide valuable incremental prognostic information, enhancing risk assessment beyond traditional factors.
  • RACI may be particularly important for prognostication in RVMI patients.
Abstract

Keywords:
acute myocardial infarctionatrioventricular coupling indexmajor adverse cardiac eventsright ventricular myocardial infarction

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.4K
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

11.6K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
32
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
46
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
72
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
51
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
37