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Updated: Sep 10, 2025

MicroRNA-based Regulation of Picornavirus Tropism

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection.

Lara Dsouza¹, Zhilong Yang¹

¹Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Journal of Medical Virology

|August 20, 2025

Summary

Viruses manipulate host cell nucleotide metabolism for replication. This review analyzes viral strategies, signaling pathways, and viral factors regulating nucleotide synthesis, crucial for developing antiviral therapies.

Keywords:

antiviral immune responses nucleotide metabolism purine pyrimidine signaling viral infection virus

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Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Published on: January 30, 2019

Area of Science:

Molecular Biology
Virology
Biochemistry

Background:

Nucleotides are essential building blocks for DNA and RNA.
Nucleotide metabolism is critical for various cellular functions and viral replication.
Viruses often alter host cell metabolism to support their lifecycle.

Purpose of the Study:

To comprehensively analyze how viruses regulate nucleotide metabolism.
To explore the role of upstream signaling pathways in viral nucleotide regulation.
To highlight knowledge gaps and emerging research in this field.

Main Methods:

Review of existing literature on viral regulation of nucleotide metabolism.
Analysis of signaling pathways exploited by various RNA and DNA viruses.
Investigation of viral factors modulating nucleotide synthesis.

Main Results:

Viruses utilize diverse mechanisms, including growth factor signaling, to control nucleotide synthesis.
Specific viral factors play key roles in modulating host nucleotide pools.
Understanding these mechanisms is vital for antiviral drug development.

Conclusions:

Viral manipulation of nucleotide metabolism is a complex process involving intricate signaling networks.
Further research is needed to elucidate the precise molecular mechanisms.
Targeting nucleotide metabolism presents a promising avenue for novel antiviral therapies.