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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Nickel-catalyzed hydroacylation of acrylates with carboxylic acids
Yuanyuan Hu1, Long Cai1, Zinuo Wang1
1College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China. zhoubw@zjut.edu.cn.
Abstract:
The nickel-catalyzed hydroacylation of acrylates with carboxylic acids is described herein. The reaction exhibits a broad substrate scope of acyl donors. Aromatic and aliphatic carboxylic acids are amenable to this reaction. Functional groups such as halogens, heteroaromatic rings, and cyano groups are well tolerated. Apart from carboxylic acid, it was demonstrated that carboxylic anhydrides, acyl chlorides, carboxylic esters, and benzothioate esters are useful acyl precursors. Mechanistic studies were carried out to elucidate the possible reaction mechanism, and it is likely that zinc benzoate is a key intermediate.
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