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Related Experiment Video

Updated: May 13, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex

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  • 1Laboratorio de Materiales para Análisis Químico (MAT4LL), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), San Cristóbal de La Laguna 38108, Spain.

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This study introduces a new method using metal-organic frameworks (MOFs) in coated-blade spray (CBS) for rapid analysis of chemicals in urine. The technique achieves high sensitivity for detecting xenobiotics in just 8 minutes.

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Ambient ionization mass spectrometry (AIMS) offers simple, high-throughput analysis.
  • Coated-blade spray (CBS) enhances sensitivity for biofluid analysis.
  • Metal-organic frameworks (MOFs) excel at trapping diverse analytes.

Purpose of the Study:

  • To integrate neat MOFs into CBS devices for xenobiotic determination in human urine.
  • To develop a novel suspect screening workflow using high-resolution mass spectrometry (HRMS).
  • To extend the chemical coverage of AIMS techniques.

Main Methods:

  • Integration of neat MOFs into CBS devices via a simple, mild strategy.
  • Development of a suspect screening workflow coupled with HRMS.
  • Analysis of xenobiotics in human urine samples.

Main Results:

  • Successful determination of xenobiotics in human urine using MOF-integrated CBS.
  • Achieved limits of quantification (LOQs) as low as 0.1 ng·mL⁻¹.
  • Demonstrated a rapid analysis time of 8 minutes for the entire procedure.

Conclusions:

  • Neat MOFs can be effectively integrated into CBS devices for sensitive xenobiotic analysis.
  • The developed HRMS suspect screening workflow expands AIMS capabilities.
  • This approach provides a rapid, sensitive, and high-quality analytical method for complex matrices like human urine.