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AGA Clinical Practice Update on Management of Hepatitis Delta: Commentary.
Tatyana Kushner1, Stanley M Cohen2, Joseph Ahn3
1Division of Gastroenterology and Hepatology, Weill Cornell School of Medicine, New York, New York.
Gastroenterology
|August 20, 2025
Summary
This clinical practice update provides guidance for managing patients with hepatitis delta virus (HDV) infection. It aims to improve understanding and clinical care for this significant liver disease.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis delta virus (HDV) infection is a severe form of viral hepatitis.
- HDV co-infection significantly worsens liver disease progression and outcomes.
Purpose of the Study:
- To provide updated clinical practice guidance for managing HDV infection.
- To enhance understanding of HDV epidemiology, diagnosis, and treatment.
Main Methods:
- This document is an American Gastroenterological Association (AGA) Clinical Practice Update.
- Developed through internal and external peer review processes.
- Commissioned by AGA leadership to address a clinically important topic.
Main Results:
- Guidance focuses on current understanding and management strategies for HDV.
- Highlights key considerations for diagnosis and treatment initiation.
- Addresses monitoring and long-term care of patients with HDV.
Conclusions:
- Optimized management of HDV infection requires a comprehensive approach.
- Adherence to updated clinical guidelines can improve patient outcomes.
- Further research is needed to advance HDV treatment options.
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