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Published on: April 19, 2013
rs.11196205 Variant in the TCF7L2 Gene is Associated with an Increased Cardiovascular Risk in Individuals with
Lívia da Cunha Agostini1, Letícia Fernandes Dias Coelho2, Renata Bárbara Machado E Silva3
1Programa de Pós-Graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
Background And Aims:
The interaction between genetic polymorphisms and environmental factors increases the risk of developing a diabetic phenotype which is associated with systemic arterial hypertension (SAH) and cardiovascular diseases. Variants in the T-cell factor 7-like 2 (TCF7L2) gene have been associated with type 2 diabetes mellitus (T2DM). To investigate the association of the rs.11196205 polymorphism of the TCF7L2 gene with biochemical and anthropometric parameters and cardiovascular risk indices in Brazilian patients with SAH and T2DM.
Methods:
The polymorphism was identified by qPCR in 664 samples from four groups: Control (CG-without diabetes or hypertension), diabetic (DG-normotensive), hypertensive (HG-without diabetes) and hypertensive diabetic (HDG), using the TaqMan® system. Biochemical dosages were taken for the lipid profile: triglycerides (TG), total cholesterol, HDL, LDL, and uric acid. Anthropometric measurements were taken for body mass index (BMI), visceral fat index and cardiovascular risk calculations, including the atherogenic index of plasma (AIP), visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid/HDL-c ratio (UA/HDL). Bivariate logistic regression was used to identify variables associated with SAH and T2DM. Subsequent categorical variables were analyzed using multinomial logistic regression.
Results:
The GG genotype of the rs.11196205 variant of the TCF7L2 gene was associated with an increased risk of hypertension and diabetic hypertension. Patients in the GHD group with the GG genotype showed worsening BMI parameters and TyG index values.
Conclusion:
The GG genotype of the rs.11196205 variant of the TCF7L2 gene acts as a cardiovascular risk genotype in patients with diabetic hypertension.
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