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Stimuli-responsive Hydrogels for Targeted Antibiotic Delivery in Bone Tissue Engineering.
Jayendra Kumar1, Tolepbergenova M2, Abdugani Musayev2
1Department of Pharmaceutical Chemistry, SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Uttar Pradesh, Delhi-NCR Campus, Modinagar, Ghaziabad, 201204, India.
AAPS Pharmscitech
|August 21, 2025
Summary
Stimuli-responsive hydrogels offer controlled antibiotic release for bone tissue engineering (BTE), addressing infection challenges. These smart hydrogels enhance healing, vascularization, and combat osteomyelitis with on-demand drug delivery.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Bone tissue engineering (BTE) struggles with osteomyelitis, where conventional antibiotics lack localized efficacy and cause toxicity.
- Effective infection management is crucial for BTE success and implant integration.
- Stimuli-responsive hydrogels present a novel approach for localized, on-demand antibiotic delivery.
Purpose of the Study:
- To review stimuli-responsive hydrogels for bone tissue engineering (BTE).
- To analyze hydrogel design, classification, and integration in BTE scaffolds.
- To explore their role in infection management and bone regeneration.
Main Methods:
- Comprehensive literature review of stimuli-responsive hydrogels in BTE.
- Analysis of hydrogel classification, design strategies, and stimuli-responsive mechanisms.
- Examination of antibiotic delivery systems and their integration into BTE scaffolds.
Main Results:
- Stimuli-responsive hydrogels enable spatiotemporal control over antibiotic release.
- These hydrogels synergistically support osteogenic differentiation and vascularization.
- Various stimuli (pH, temperature, redox) trigger drug release, overcoming limitations of conventional therapies.
Conclusions:
- Stimuli-responsive hydrogels are a promising strategy for precision antibiotic delivery in BTE.
- They offer enhanced infection control and improved bone regeneration outcomes.
- Future directions include biosensing, 3D-bioprinting, and AI-assisted platforms for advanced BTE solutions.
