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Updated: Sep 10, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Syntheses, Crystal Structures and Antimicrobial Activity of N,N'-Bis(4-bromosalicylidene)propane-1,2-diamine and Its
1Baicheng Normal University. jyxygzb@163.com.
None:
A new bis-Schiff base N,N'-bis(4-bromosalicylidene)propane-1,2-diamine (H2L) and its two copper(II) complexes, [CuL] (1) and [Cu4Cl2L2(N3)2]·CH3OH (2), have been prepared and characterized by spectroscopy methods, as well as single crystal X-ray diffraction. The Cu atom in the mononuclear complex 1 is in square planar coordination. The outer and inner Cu atoms in the phenolate and azide co-bridged tetranuclear complex 2 are in square planar and square pyramidal coordination, respectively. The antibacterial activities of the Schiff base and the two copper complexes have been assayed on the bacteria Staphylococcus aureus and Escherichia coli, and the yeast Candida parapsilosis.
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