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Updated: Sep 10, 2025

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Published on: May 9, 2018
[Occupational hypersensitivity pneumonitis : when to think about it]
Arnaud Montavon1, Nahal Mansouri2,3, Pieter-Jan Gijs2
1Service de médecine interne, Département de médecine interne, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Abstract:
Occupational hypersensitivity pneumonitis is an immune-mediated disease affecting the pulmonary interstitium and airways, caused by the inhalation of antigens present in the workplace environment. A rigorous diagnostic approach is essential because, if unrecognized, this condition can progress to irreversible fibrosing disease. To confirm a diagnosis of hypersensitivity pneumonitis, it is necessary to consider respiratory symptoms, high-resolution computed tomography (HRCT) imaging and bronchoscopy. A detailed occupational exposure history is crucial to identifying the causative antigen. Treatment primarily involves avoiding exposure to the offending antigen. In more severe cases, immunosuppressive or antifibrotic therapy may be required.
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