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Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
Published on: June 2, 2023
Recent innovations in targeting redox biology for therapeutics
Miriam M Cortese-Krott1,2, Jon M Fukuto3, Amrita Ahluwalia4
1Department of Cardiology, Pulmonology, and Angiology, Medical Faculty, Myocardial Infarction Research Laboratory, Heinrich-Heine-University, Düsseldorf, Germany.
None:
Redox signalling governs key physiological and pathological processes, offering diverse therapeutic targets across disease contexts. This editorial introduces a special issue of the British Journal of Pharmacology highlighting recent advances in redox biology, including novel small molecules, non-canonical nitric oxide and hydrogen sulfide pathways, epigenetic modulation and immune regulation. Together, these contributions illustrate the translational potential of redox-targeted pharmacology and outline future directions for innovation in the field. LINKED ARTICLES: This article is part of a themed issue Recent Innovations in Targeting Redox Biology for Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v183.1/issuetoc.
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