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Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer
Sanchita Ghosh1,2, Weibo Cai3, Rubel Chakravarty1,2
1Radiopharmaceuticals Division Bhabha Atomic Research Centre Trombay Mumbai 400085 India.
Small Science
|August 21, 2025
Summary
Radiolabeled nanogels (NGs) offer advanced cancer theranostics by combining multimodality imaging with synergistic therapies. This nanotechnology enables precise tumor visualization and targeted treatment, improving efficacy and reducing toxicity for better patient outcomes.
Area of Science:
- Nanotechnology
- Oncology
- Radiochemistry
Background:
- Nanotechnology advancements have opened new avenues for cancer theranostics.
- Radiolabeled nanogels (NGs) are emerging as a versatile platform for integrated imaging and therapy.
Purpose of the Study:
- To review the progress and potential of radiolabeled NGs in cancer research.
- To highlight their role in multimodality imaging and combination therapy.
Main Methods:
- Utilizing radiolabeled NGs as contrast agents for various imaging modalities (PET, SPECT, optical, MRI).
- Incorporating multiple therapeutic payloads (chemotherapeutics, nucleic acids, radionuclides) for synergistic effects.
- Employing radiolabeling for real-time monitoring of drug distribution and pharmacokinetics.
Main Results:
- Radiolabeled NGs enable precise tumor visualization and site-specific imaging.
- Combination therapy with NGs addresses cancer cell heterogeneity and microenvironment.
- Real-time monitoring provides insights into treatment response and optimization.
Conclusions:
- Radiolabeled NGs represent a significant advancement in integrated cancer imaging and therapy.
- This platform enhances therapeutic efficacy while minimizing systemic toxicity.
- The approach promises improved patient outcomes in cancer treatment.
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