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Diversity-Enhanced Collaborative Mamba for Semi-Supervised Medical Image Segmentation.

Shumeng Li, Jian Zhang, Lei Qi

    IEEE Transactions on Medical Imaging
    |August 21, 2025
    PubMed
    Summary

    We introduce DCMamba, a novel framework for semi-supervised medical image segmentation. It significantly improves segmentation accuracy by leveraging data, network, and feature diversity, outperforming existing methods.

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    Area of Science:

    • Medical image analysis
    • Computer vision
    • Machine learning

    Background:

    • High-quality annotated medical data is expensive and time-consuming to acquire.
    • Semi-supervised learning reduces annotation burden by using unlabeled data for pseudo-labeling.
    • State space models like Mamba excel at capturing long-range dependencies.

    Purpose of the Study:

    • To explore the potential of advanced state space models in semi-supervised medical image segmentation.
    • To propose a novel framework, DCMamba, enhancing diversity across data, network, and features.

    Main Methods:

    • Developed patch-level weak-strong mixing augmentation tailored for Mamba's scanning.
    • Introduced a diverse-scan collaboration module to leverage directional prediction discrepancies.
    • Implemented uncertainty-weighted contrastive learning to enrich feature representation diversity.

    Main Results:

    • DCMamba demonstrated superior performance in semi-supervised medical image segmentation.
    • Achieved a 6.69% improvement over the latest SSM-based method on the Synapse dataset with 20% labeled data.

    Conclusions:

    • DCMamba effectively utilizes data, network, and feature diversity for improved semi-supervised segmentation.
    • The proposed framework offers a promising direction for efficient medical image segmentation with limited annotations.