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Updated: Sep 10, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Nickel-Catalyzed Selective Monoamination of 1,2-Diols: An Affordable Approach to Amino Alcohols
Soumya Sree Samal1, Murugan Subaramanian1, Ekambaram Balaraman1,2
1Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517619, India.
Abstract:
The development of catalytic systems based on earth-abundant metals for sustainable and affordable chemical synthesis remains a significant challenge. In this work, we report a highly efficient and selective nickel-catalyzed monoamination of 1,2-diols to access β-amino alcohols. The reaction proceeds under mild and benign conditions and exhibits a broad substrate scope with excellent functional group tolerance. Mechanistic studies reveal that the transformation occurs through double dehydrogenation of diols, followed by selective monoamination via a transfer hydrogenation/borrowing hydrogen tandem process.
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