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PANoptosis in cancer: molecular mechanisms and therapeutic potential

Xi Pu1,2, Yuting Wu1, Chen Peng3

  • 1Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.

Cancer Gene Therapy
|August 21, 2025
PubMed

Insights

PANoptosis, a novel cell death pathway, integrates pyroptosis, apoptosis, and necrotic cell death. Understanding PANoptosis offers new therapeutic strategies for cancer by targeting its role in tumor initiation, progression, and immunity.

Area of Science:

  • Cellular Biology
  • Immunology
  • Oncology

Background:

  • Tumorigenesis is linked to dysregulated cell death.
  • PANoptosis is a newly identified programmed cell death pathway.
  • PANoptosis involves the PANoptosome complex, integrating pyroptosis and apoptosis features.

Purpose of the Study:

  • To review the characteristics and mechanisms of PANoptosis.
  • To discuss the role of PANoptosis in cancer biology and tumor immunity.
  • To explore therapeutic strategies targeting PANoptosis in cancer.

Main Methods:

  • Literature review of programmed cell death pathways.
  • Analysis of PANoptosis assembly and molecular features.
  • Discussion of PANoptosis implications in cancer and immunity.

Main Results:

  • PANoptosis integrates features of pyroptosis, apoptosis, and necrotic cell death.
  • The PANoptosome is a key multiprotein complex in PANoptosis.
  • PANoptosis influences cancer initiation, progression, and the tumor microenvironment.

Conclusions:

  • PANoptosis plays a significant role in cancer biology.
  • Targeting PANoptosis presents a promising therapeutic avenue for cancer treatment.
  • Further research into PANoptosis could revolutionize cancer therapy.

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