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Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal
Andrea Arroyave1,2, Henintsoa Rabezanahary1,2, Aude Wantchecon1,2
1Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Quebec, Quebec, Canada.
Abstract:
This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity against seasonal strains, no cross-reactivity against H5N1 was detected, emphasizing the need to assess broader immune responses and targeted vaccines for H5N1 viruses.
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