Related Experiment Video
Updated: Sep 10, 2025
Real-Time Void Spot Assay
Published on: February 10, 2023
U-shaped association between ultra-processed food intake and overactive bladder in US adults: a national
Zufa Zhang1,2, Li Chen3, Long Lv1,4
1Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Background:
The association between ultra-processed food (UPF) intake and overactive bladder (OAB) remains unclear. This study aimed to investigate the relationship between UPF consumption and the risk of OAB in U.S. adults.
Methods:
We conducted a cross-sectional analysis using data from 23,482 participants in the National Health and Nutrition Examination Survey (NHANES). UPF intake was assessed in g/day and kcal/day. Perform a natural logarithmic conversion of the UPF with e as the base. Weighted multivariable logistic regression was used to evaluate the association between UPF intake and OAB. Subgroup and interaction analyses were performed to assess effect modification. Restricted cubic spline (RCS) models were applied to explore potential non-linear relationships. Threshold effect analyses were conducted to identify inflection points.
Results:
UPF intake was positively associated with the risk of OAB in both continuous and categorical analyses. A U-shaped non-linear relationship between UPF intake and OAB risk was identified, with inflection points at 6.33 (g/day) and 5.73 (kcal/day). Subgroup analyses revealed stronger associations among women, smokers, and overweight or obese individuals. Interaction tests indicated significant modification effects by sex and smoking status.
Conclusion:
This study suggests a U-shaped association between specific levels of UPF intake and OAB risk among U.S. adults. Further prospective studies are needed to validate these findings and explore the underlying biological mechanisms.
Related Concept Videos
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
01:20Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
01:26The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations