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Updated: Sep 10, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Steric hindrance engineering to construct NIR-II probe for high-sensitivity G4 imaging in vivo
Hong-Ya Xiang1, Yi-Feng Ou1, Ren-Xuan Wang1
1State Key Laboratory of Chemo/Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. zjl1046@hnu.edu.cn.
None:
G-Quadruplexes play key roles in tumorigenesis, but detecting them in vivo remains challenging. We developed NIRGQ-3, a NIR-II fluorescent probe, with 25-fold fluorescence enhancement and improved sensitivity (limit of detection: 35 nM). It enables high-contrast tumor imaging (SBR = 25), providing a powerful tool to decipher G-quadruplex dynamics and advancing cancer diagnostics.
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