Combination Therapy With Poly D-L Lactic Acid and Autologous Fat Transplantation for Infraorbital Rejuvenation

Area of Science:

• Aesthetic Medicine
• Regenerative Medicine
• Dermatology

Background:

• Infraorbital hollowing is commonly treated with hyaluronic acid fillers or autologous fat transfer.
• Traditional methods have limitations like the Tyndall effect and variable fat retention.

Purpose of the Study:

• To assess the efficacy and safety of a new combination therapy for infraorbital rejuvenation.
• The therapy combines poly-D,L-lactic acid (PDLLA) with autologous fat transplantation.

Main Methods:

• Eight female patients with infraorbital hollowing received the combination treatment.
• Two PDLLA formulations were used: standard for dermal and volume for subdermal injection.
• Fat was harvested, centrifuged, and injected using a multilayer technique; follow-up was 6-14 months.

Main Results:

• All patients showed significant improvement in hollowing and skin quality.
• Enhanced fat graft retention and improved skin texture were observed.
• High patient satisfaction and no significant complications were reported.

Conclusions:

• PDLLA combined with autologous fat transfer is an effective infraorbital rejuvenation method.
• This combination offers superior results to single-modality treatments.
• The technique provides improved fat graft retention, skin quality, and a favorable safety profile.