Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

40.4K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.4K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

5.8K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
5.8K
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

6.4K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
6.4K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

5.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
5.8K
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

4.6K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.6K
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

5.6K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Cyclododecane-based high-intactness and clean transfer method for fabricating suspended two-dimensional materials.

Nature communications·2026
Same author

REPLY TO: Questioning the near-intrinsic thermal conductivity of suspended graphene membranes fabricated via a cyclododecane-based transfer method.

Nature communications·2026
Same author

The 2024 report of the synergetic roadmap on carbon neutrality and clean air for China: Pollution and carbon reduction promote green economic development.

Environmental science and ecotechnology·2025
Same author

Intensive anthropogenic activities drive dynamic surface water-groundwater interactions: Implications for contaminant pathways at a catchment scale.

Journal of contaminant hydrology·2025
Same author

Deciphering runoff-sediment-nutrient dynamics in agricultural watersheds supplied by large feeder Rivers: A multi-scale analysis.

Journal of contaminant hydrology·2025
Same author

Discussion on the association between domestic water hardness and kidney stone disease: insights from the UK Biobank study.

International journal of surgery (London, England)·2025

Related Experiment Video

Updated: May 6, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

13.0K

Mapping early corpus callosum development to identify neurodevelopmental risk.

Boyang Mao1, Hongxi Zhang2, Haitao Wang3

  • 1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; School of Psychology and Mental Health, North China University of Science and Technology, Hebei, China; Hebei Key Laboratory of Mental Health and Brain Science, China.

Developmental Cognitive Neuroscience
|August 22, 2025
PubMed
Summary

Sex-specific models reveal typical corpus callosum development in children. These models accurately identify Autism Spectrum Disorder (ASD) by detecting atypical brain growth, aiding early diagnosis.

Keywords:
And Early DetectionAutismCorpus CallosumGrowth Curve ModelGrowth CurvesNeurodevelopmental

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.1K

Related Experiment Videos

Last Updated: May 6, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

13.0K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.1K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Corpus callosum development is crucial for cognitive maturation.
  • Altered corpus callosum morphology is implicated in Autism Spectrum Disorder (ASD).
  • Understanding typical, sex-specific development is essential for identifying neurodevelopmental deviations.

Purpose of the Study:

  • To develop sex-specific normative growth curve models for early childhood corpus callosum development.
  • To assess the generalizability of these models in distinguishing children with ASD from typically developing children (TDC).

Main Methods:

  • Utilized structural Magnetic Resonance Imaging (MRI) data from 295 typically developing children (aged 1-6 years).
  • Modeled age- and sex-dependent changes in ten corpus callosum morphometric parameters.
  • Applied normative models to an independent dataset including children with ASD.

Main Results:

  • Identified nonlinear developmental trajectories and region-specific growth rates.
  • Observed earlier developmental peaks in females compared to males.
  • Classifiers based on deviations from growth curves achieved high accuracy (AUC = 0.95) in distinguishing ASD from TDC.

Conclusions:

  • Established sex-specific corpus callosum growth curve models as a quantitative and generalizable tool.
  • Demonstrated the potential for early, objective ASD diagnosis using these morphometric models.
  • Highlighted the utility of these models for facilitating timely intervention in neurodevelopmental disorders.