Related Experiment Video
Updated: May 6, 2026
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
The Age-Male-Albumin-Bilirubin-Platelet Risk Score Predicts Postoperative Prognosis of Intrahepatic
1Liver Transplant Center & Laboratory of Liver Transplantation, West China Hospital of Sichuan University, Chengdu, China; Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital of Sichuan University, Chengdu, China; Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China.
Introduction:
The age-male-albumin-bilirubin-platelets (AMAP) score serves as a specific model for assessing liver fibrosis among individuals with chronic hepatitis B. However, there remains ambiguity regarding its ability to reliably predict the long-term outcomes for patients diagnosed with intrahepatic cholangiocarcinoma (ICC) after undergoing radical surgical interventions.
Methods:
This retrospective multicenter investigation included 681 participants diagnosed with ICC who had undergone radical surgical procedures. The AMAP risk score was computed according to the following equation: (0.06 × age + 0.48 × ALBI - 0.01 × platelet + 7.4)/14.77 × 100. To assess the clinical significance of the AMAP score on survival outcomes, Kaplan-Meier methods, log-rank tests, and Cox proportional hazards regression models were utilized. In addition, a nomogram was created utilizing the outcomes of the multivariate analysis.
Results:
The AMAP model demonstrated a significant correlation with the rates of disease-free survival (DFS) and overall survival (OS) in individuals diagnosed with ICC. Patients in the low-risk group exhibited significantly longer DFS (P = 0.002) and OS (P < 0.001) compared to those in the high-risk group. In addition, a nomogram was constructed to predict DFS, achieving a C-index of 0.705, and for OS, a C-index of 0.753. The nomogram based on AMAP demonstrates strong predictive performance.
Conclusions:
The AMAP score functions as a prospective prognostic indicator for individuals diagnosed with ICC. A nomogram incorporates the AMAP score proves valuable in recognizing patients with ICC who are at high risk and supports the creation of adjuvant treatment plans.
Related Concept Videos
01:26Blood Studies I: ABG and VBG
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...