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Updated: Sep 10, 2025

Purification of Transcripts and Metabolites from Drosophila Heads
Published on: March 15, 2013
Epitranscriptomic dysregulation in neurodegenerative diseases and its implications for disease pathology and
1Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Abstract:
RNA modifications, collectively referred to as the epitranscriptome, play a crucial role in regulating RNA metabolism, influencing key processes such as splicing, stability, localization, and translation. Increasing evidence now links dysregulation of the epitranscriptome to neurodegenerative diseases. In this review, we focus on four RNA modifications and their influence on neurodegenerative pathways, including synaptic function, neuroinflammatory signaling, and stress granule formation. These findings highlight the complex and multifaceted roles that RNA modifications play in neurodegeneration, emphasizing their emerging potential as biomarkers and therapeutic targets.
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