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Metabolic Remapping at "Point-Line-Plane" Levels With Central Dysfunction in Cerebral Small Vessel Disease
Jie Ma1,2, Juan-Juan Lu1,2, Xin Gao3
1Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Brain and Behavior
|August 23, 2025
Summary
Cerebral small vessel disease (CSVD) alters brain glucose metabolism heterogeneously across networks, beginning at the region and connectivity levels. These findings reveal intricate metabolic changes in CSVD patients.
Area of Science:
- Neuroimaging
- Metabolic Neuroscience
- Cerebrovascular Diseases
Background:
- Cerebral small vessel disease (CSVD) affects glucose metabolism.
- Understanding CSVD's metabolic impact at network levels is crucial.
Purpose of the Study:
- Investigate glucose metabolic patterns in CSVD using FDG-PET/MRI.
- Analyze metabolic changes at regional, network, and connectivity levels.
Main Methods:
- Retrospective analysis of 174 CSVD patients and 206 controls using 18F-fluorodeoxyglucose PET/MRI.
- Divided brain into 7 networks, calculating mean standard uptake value (SUVmean).
- Compared SUVmean across regions, networks, and assessed metabolic connectivity and correlations.
Main Results:
- CSVD group showed increased SUVmean in right postcentral and superior parietal gyri.
- Decreased SUVmean was observed in the right superior temporal gyrus.
- Significant correlations found between network SUVmean alterations and regional metabolism.
Conclusions:
- Glucose metabolism redistribution in CSVD is heterogeneous across brain networks.
- Metabolic changes in CSVD originate from regional alterations and sub-network connectivity.
- Findings highlight complex metabolic network disruptions in CSVD.
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