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Related Experiment Videos

The CSF pulse wave in hydrocephalus.

H D Portnoy, C Branch, M Chopp

    Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
    |January 1, 1985
    PubMed
    Summary
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    Cerebrospinal fluid (CSF) pulse wave transmission in hydrocephalic dogs is independent of hydrocephalus. The pulse wave does not cause hydrocephalus, suggesting it originates from cerebrovascular processing of cardiac pulse waves.

    Area of Science:

    • Neuroscience
    • Physiology
    • Comparative Medicine

    Background:

    • Hydrocephalus is a condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) within the brain's ventricles.
    • The relationship between CSF pulse wave dynamics and the development or progression of hydrocephalus remains incompletely understood.

    Purpose of the Study:

    • To investigate the transmission of arterial pulse waves into the cerebrospinal fluid (CSF) in a canine model of hydrocephalus.
    • To determine if CSF pulse wave characteristics correlate with the severity of hydrocephalus or if they contribute to its pathogenesis.

    Main Methods:

    • Induction of hydrocephalus in 21 dogs using intracisternal kaolin injection.
    • Measurement of arterial, ventricular, and sagittal sinus pressures at various intervals post-induction.

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  • Serial brain sectioning and ventricular size measurement following sacrifice.

    • Main Results:

    • Ventricular size generally increased with longer incubation periods.
    • No correlation was found between hydrocephalus severity and mean or pulsatile ventricular pressure.
    • CSF pulse wave transmission (linear vs. non-linear) correlated with CSF pressure, mirroring findings in non-hydrocephalic states.

    Conclusions:

    • The observed CSF pulse wave in hydrocephalic dogs is attributed to the cerebrovascular bed's processing of the cardiac pulse wave, independent of the hydrocephalic condition.
    • There is no evidence to suggest that the CSF pulse wave actively produces or exacerbates hydrocephalus.