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Updated: May 3, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Transport-Related Risk Factors for Intraventricular Hemorrhage in Preterm Neonates: An Exploratory Analysis.

Colleen Butler1, Julianne Olshannikov1, Jennifer Watts1

  • 1Advocate Children's Hospital Neonatal Pediatric Transport Program, Elmhurst, IL.

Air Medical Journal
|August 23, 2025
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Summary
This summary is machine-generated.

Intraventricular hemorrhage (IVH) in preterm infants is linked to maternal infections and infant positioning during transport. Male neonates and midline positioning were associated with IVH, emphasizing modifiable factors for prevention.

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Area of Science:

  • Neonatal care
  • Transport medicine
  • Neuroprotection

Background:

  • Preterm neonates are at high risk during ground transport.
  • Neuroprotection is crucial to prevent intraventricular hemorrhage (IVH).
  • Transport-related factors contributing to IVH are not well understood.

Purpose of the Study:

  • Identify transport-related factors associated with IVH in preterm neonates.
  • Examine the link between critical ground transport parameters and clinical IVH factors.
  • Assess the impact of maternal and fetal factors on IVH development.

Main Methods:

  • Retrospective study using electronic health records from two Midwest transport teams.
  • Logistic regression models were employed to analyze transport and maternal variables.
  • Data from 79 preterm neonates were analyzed.

Main Results:

  • 25 (31.6%) neonates developed IVH.
  • Higher IVH incidence observed in male neonates (P = .02).
  • Midline positioning was associated with IVH status (P = .03).
  • Maternal infection significantly correlated with IVH (OR = 6.17, P = .0288).
  • No association found between critical ground transport factors and IVH rates.

Conclusions:

  • Maternal infections and infant positioning are modifiable factors for IVH prevention.
  • Optimizing ground transport practices is essential, especially for male neonates.
  • Further research into transport-related IVH factors is warranted.