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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

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Functional exercise training in persons with multiple sclerosis: a systematic review.

Frederike Adammek^1,2, Weronika Gralla^3,4, Marie Kupjetz¹

¹Research Group "Sports Medicine", Institute for Sport and Sport Science, TU Dortmund University, 44227, Dortmund, Germany.

Journal of Neurology

|August 23, 2025

Summary

This summary is machine-generated.

Functional exercise training shows promise for improving mobility, balance, and quality of life in people with Multiple Sclerosis (pwMS). Further research is needed to standardize definitions and assess long-term effects.

Keywords:

Exercise Functional exercise Functional training Rehabilitation

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Area of Science:

Neurology
Rehabilitation Medicine
Exercise Science

Background:

Functional exercise training enhances everyday movement capacity through strength, stability, balance, coordination, and flexibility.
Less standardized approaches like functional exercise training may benefit persons with Multiple Sclerosis (pwMS), but require further investigation.
Existing research on functional exercise training in pwMS is limited, necessitating a comprehensive literature review.

Purpose of the Study:

To review the effects of functional exercise training on functional outcomes, physical and physiological measures, and patient-reported outcomes in pwMS.
To synthesize findings on mobility, walking capacity, balance, proprioception, strength, endurance, Quality of Life, and Fatigue.
To identify gaps in the literature regarding functional exercise training for pwMS.

Main Methods:

Systematic review conducted following PRISMA guidelines.
Literature search in Medline (PubMed) and Cochrane CENTRAL up to February 19, 2025.
Included 19 studies (pilot to RCTs) on adult pwMS, assessing outcomes with the TESTEX tool.

Main Results:

Included interventions ranged from 6 to 16 weeks, with highly heterogeneous results.
Some studies reported improvements in mobility, walking capacity, balance, strength, endurance, Quality of Life, and fatigue.
Treatment adherence reporting was consistently poor across studies.

Conclusions:

Functional exercise training offers a comprehensive approach for pwMS, potentially improving function, strength, and endurance.
A clear definition of functional exercise training is needed for consistency.
Future research should focus on standardized reporting of adherence and long-term effects in pwMS.