Related Experiment Video
Updated: Sep 10, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
Published on: June 16, 2023
Long Non-Coding RNA SNHG22 in Prognosis for Solid Tumors: A Systematic Review and Meta-Analysis
Thang Thanh Phan1,2, Hang Thuy Nguyen3, Phu Thien Truong2,4
1Department of Molecular Biomedicine, Gia An 115 Hospital, HCMC, 700000, Vietnam.
Objectives:
Small nucleolar RNA host gene 22 (SNHG22) is a novel long non-coding RNA (lncRNA) that functions as an oncogene and promotes the progression of various cancers. This pooled analysis aimed to clarify the prognostic role of SNHG22 in solid tumors and to explore its correlation with disease characteristics.
Methods:
We conducted a comprehensive search in databases such as PubMed/MEDLINE, Web of Science, Cochrane Library, and Google Scholar for relevant articles published until January 8, 2025. We combined individual data to estimate the overall hazard ratio (HR) for cancer prognosis. Additionally, We assessed the relationships between SNHG22 expression levels and patient characteristics using the odds ratio (OR).
Results:
Nine studies involving 779 patients participated in the analysis. Patients with SNHG22 overexpression exhibited poorer overall survival (HR=2.44, 95% confidence interval [CI]: 1.98-3.01, I2=0%) and recurrence-free survival (HR=2.60, 95%CI: 1.69-4.00, I2=0%) compared to those with lower levels. Furthermore, higher SNHG22 expression was significantly associated with larger tumor size (OR=2.65, 95%CI: 1.13-6.22), lymph node metastasis (OR=2.12, 95%CI: 1.16-3.86), and advanced disease stages (OR=2.54, 95%CI: 1.73-3.72).
Conclusion:
The upregulation of SNHG22 is associated with shorter survival outcomes, increased tumor size, lymph node metastases, and more advanced tumor stages.
More Related Videos
07:23Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Related Concept Videos
lncRNA - Long Non-coding RNAs
MicroRNAs
RNA Splicing
Non-LTR Retrotransposons