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Endothelial permeability increase produced by angiographic contrast media
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|October 1, 1979
Summary
Radiographic contrast media can damage aortic endothelial cells. The extent of damage from these agents, including metrizamide and methylglucamine salts, depends on their chemical structure and osmolality.
Area of Science:
- Vascular biology
- Radiology
- Toxicology
Background:
- Endothelial damage is a concern with angiographic contrast media.
- Understanding the factors influencing this damage is crucial for patient safety.
Purpose of the Study:
- To evaluate the impact of different methylglucamine-based contrast agents and metrizamide on thoracic aortic wall permeability in rats.
- To correlate endothelial damage with the chemical structure and osmolality of these agents.
Main Methods:
- Light microscopy with silver staining was used to assess aortic wall permeability changes.
- Constant iodine concentration was maintained across tested contrast media.
- Osmolality of each contrast agent was determined.
Main Results:
- Statistically significant differences in endothelial damage were observed among the contrast media.
- Agents were grouped by increasing endothelial damage: Metrizamide/methylglucamine diatrizoate, methylglucamine metrizoate (with calcium)/methylglucamine iodamide, and methylglucamine iothalamate.
- Ionic agents exhibited similar hypertonicity; metrizamide was nearly isotonic.
Conclusions:
- Endothelial damage from radiographic contrast media is influenced by both chemical structure and hypertonicity.
- Metrizamide and methylglucamine diatrizoate showed the least endothelial damage.
- Methylglucamine iothalamate caused the most significant endothelial damage.