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Novel and optimized diagnostics for pediatric TB in endemic countries: NOD-pedFEND study protocol
Rinn Song1, Else Margreet Bijker2,3, Grace Kisitu4
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. rinn.song@paediatrics.ox.ac.uk.
BMC Pediatrics
|August 24, 2025
Summary
Accurate diagnosis of pediatric tuberculosis (TB) is crucial. This large study in young children aims to improve diagnostic tests for TB, especially using non-sputum samples, to aid treatment and public health efforts.
Area of Science:
- Global Health
- Infectious Diseases
- Pediatric Medicine
Background:
- Pediatric tuberculosis (TB) poses a significant global health challenge.
- Accurate diagnosis is a major barrier to effective treatment in children.
- Current diagnostic studies are limited by small sample sizes and few confirmed cases.
Purpose of the Study:
- To evaluate existing and novel diagnostic assays for pediatric tuberculosis.
- To enroll one of the largest cohorts of children at high risk for TB.
- To improve diagnostic capabilities, particularly in children under five years of age.
Main Methods:
- Prospective observational cohort study in Uganda and Peru.
- Enrollment of children under five with suspected TB symptoms.
- Comprehensive baseline workup including microbiological tests, chest X-ray, and sample collection for investigational tests.
Main Results:
- This section is not applicable for the protocol description.
- This section is not applicable for the protocol description.
- This section is not applicable for the protocol description.
Conclusions:
- This large cohort study will significantly contribute to evaluating new pediatric TB diagnostics.
- The established biorepository will facilitate assessment of novel tests.
- Findings will aid in identifying and treating children with tuberculosis more effectively.
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