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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Esophageal Perforation-II: Clinical Manifestations and Management01:28

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Related Experiment Video

Updated: Sep 10, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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A 48-hour Symptom Threshold Predicts Perforated Appendicitis: Development of a Clinical Risk Model.

Masato Fujino1, Shingo Ochiai2, Tadao Kubota3

  • 1Department of Surgery, Tokyo Kita Medical Centre, Tokyo, Japan.

World Journal of Surgery
|August 24, 2025
PubMed
Summary
This summary is machine-generated.

A delay of 48 hours or more from symptom onset significantly increases the risk of perforated appendicitis. This finding aids in developing a predictive model for acute appendicitis perforation.

Keywords:
48‐h time lapseC‐reactive protein (CRP)acute appendicitisappendicolithrisk of perforationsymptom onset

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Area of Science:

  • Medical research
  • Surgical outcomes
  • Predictive modeling

Background:

  • Predicting acute appendicitis perforation at admission is crucial for treatment.
  • This study evaluates the impact of symptom onset to hospital presentation time on perforation risk.

Purpose of the Study:

  • To assess the correlation between time from symptom onset to hospital presentation and the risk of appendicitis perforation.
  • To develop a predictive model for appendicitis perforation incorporating key clinical factors.

Main Methods:

  • Retrospective analysis of 414 patients undergoing appendectomy for acute appendicitis.
  • Patients were grouped by symptom onset to presentation time (0-96+ hours).
  • Statistical analysis included ROC analysis and calculation of adjusted odds ratios.

Main Results:

  • Perforation risk escalates with longer time intervals (p < 0.01).
  • A 48-hour interval is an independent risk factor (adj OR = 3.30).
  • Elevated CRP (adj OR = 5.12) and appendicolith (adj OR = 2.38) also increase perforation risk.

Conclusions:

  • A 48-hour symptom onset to presentation cutoff effectively predicts appendicitis perforation.
  • A predictive model combining time lapse, CRP, and appendicolith presence is proposed.