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A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
Obesity And The Spleen
Sanjay Kalra1, Suneet Kumar Vermaz2, Nitin Kapoor3
1Department of Endocrinology, Bharti Hospital, Karnal, India; University Centre for Research& Development, Chandigarh University, Mohali, India.
Abstract:
This review describes the relationship of splenomegaly, or "splenic obesity", with metabolic syndrome, obesity and metabolic - associated steatohepatic disease (MAFLD), based on animal and human studies. The spleen is enlarged in obesity. It may play a protective role against obesity-associated inflammation and complications. This protection may be lost after splenomegaly. Persons with splenic disease must be evaluated for obesity, and vice versa and counselled to avoid injury to the organ.
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