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Analysis of Risk Factors for the Recurrence of Chronic Tic Disorder in Children

Miao Jing1, Yanping Wang1, Jingbo Ma1

  • 1Department of Neurology, The Affiliated Wuxi Children's Hospital of JiangNan University, Wuxi, Jiangsu Province, China.

Journal of Paediatrics and Child Health
|August 25, 2025
PubMed

Insights

Mycoplasma infection and vocal tics are key risk factors for chronic tic disorder recurrence in children. Older age and aripiprazole treatment may protect against relapse after medication discontinuation.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Clinical Psychology

Background:

  • Chronic tic disorders (CTDs) affect children, with recurrence posing a challenge after treatment.
  • Identifying predictors of relapse is crucial for optimizing long-term management strategies.

Purpose of the Study:

  • To determine risk factors for recurrence in pediatric patients with CTDs.
  • To evaluate factors associated with relapse 6 months after medication discontinuation.

Main Methods:

  • A hybrid study design involving 124 pediatric patients with CTDs.
  • Comparison of clinical data between relapse and no-relapse groups post-treatment.
  • Multivariate binary logistic regression analysis to identify independent risk factors.

Main Results:

  • Mycoplasma pneumoniae antibody IgM and vocal tics were significant risk factors for recurrence (OR=4.797 and OR=8.202, respectively).
  • Increased age and aripiprazole treatment were identified as protective factors against recurrence (OR=0.519 and OR=0.091, respectively).
  • Significant differences between groups were observed in age, white blood cell count, Mycoplasma antibody levels, tic characteristics, and medication use.

Conclusions:

  • Mycoplasma infection and vocal tics are significant risk factors for CTD recurrence in children.
  • Aripiprazole treatment and older age may offer protection against relapse.
  • Findings can inform clinical management to reduce recurrence rates in pediatric CTDs.
Abstract

Keywords:
Mycoplasma pneumoniae antibody IgMaripiprazolechronic tic disorders in childrenrecurrence risk factorsvocal tics

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