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Updated: Sep 10, 2025
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
279
Glycosylation in kidney diseases
Yingying Ling1, Fei Cai1, Tao Su1
1Department of Nephrology, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Precision Clinical Medicine
|August 25, 2025
Summary
Protein glycosylation, a key modification affecting protein function, is increasingly studied in kidney disease pathogenesis. Understanding its aberrant changes offers potential for new diagnostics and therapies.
Area of Science:
- Biochemistry
- Molecular Biology
- Nephrology
Background:
- Protein glycosylation is a vital post-translational modification impacting protein structure and function.
- Aberrant glycosylation is linked to various diseases, including genetic disorders and immune system dysfunction.
- Glycoproteomic advancements highlight protein glycosylation's role in kidney disease.
Purpose of the Study:
- To provide a comprehensive review of protein glycosylation in renal physiology and pathology.
- To examine aberrant glycosylation in specific kidney diseases.
- To discuss clinical applications and therapeutic strategies.
Main Methods:
- Literature review of protein glycosylation mechanisms and roles.
- Analysis of glycoproteomic data and research on kidney diseases.
- Evaluation of clinical technologies and biomarker applications.
Main Results:
- Protein glycosylation is crucial for kidney function; alterations are implicated in diseases like IgA nephropathy, diabetic kidney disease, and renal cell carcinoma.
- Dynamic changes and regulatory networks of aberrant glycosylation are significant in various kidney pathologies.
- Clinical applications and challenges in glycosylation-targeted therapies are identified.
Conclusions:
- Further research is needed to elucidate kidney-specific glycosylation networks.
- Integrating glycobiology with multi-omics approaches is essential for advancing kidney disease research.
- Improved precision diagnostics and therapeutics for kidney diseases can emerge from a deeper understanding of glycosylation.
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