Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning inspired compact quad port MIMO antenna with circular polarization for multi band wireless applications.

Scientific reports·2026
Same author

Compact dual-band four-port MIMO patch antenna with inverse U-shaped resonators and defected ground structure for wireless communication applications.

Scientific reports·2026
Same author

In Vivo Study of Intra-articular Tualang Honey Formulation as a Potential Alternative to Synvisc® in an Osteoarthritic Rabbit Model.

Malaysian orthopaedic journal·2026
Same author

Oral Curcumin for Tendon Health: An Appraisal on Carrier Systems, Bioenhancers, and Synergistic Formulations.

Journal of dietary supplements·2026
Same author

A randomised controlled study on the synergistic effects of neuroplasticity-based interventions for trunk control in post-stroke rehabilitation.

The Medical journal of Malaysia·2025
Same author

The effects of transcranial direct current stimulation on serum superoxide dismutase levels in ambulatory ischaemic stroke patients: A randomised pilot study.

The Medical journal of Malaysia·2025

Related Experiment Video

Updated: Sep 10, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

8.4K

Radiographical Assessment of Injectable Calcium Phosphate Bone Cement (Osteopaste) in Critical Size Bone Defects of

Cnz Che-Seman1, Z Zakaria2, Z Buyong3

  • 1Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Malaysia.

Malaysian Orthopaedic Journal
|August 25, 2025
PubMed
Summary
This summary is machine-generated.

Osteopaste, a synthetic bone graft, effectively bridges critical size bone defects through new bone formation by 12 weeks. This tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) cement shows promising results for bone healing applications.

Keywords:
bone formationcalcium phosphatecalcium sulphatecritical size defectosteointegration

More Related Videos

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

9.1K
Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

169

Related Experiment Videos

Last Updated: Sep 10, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

8.4K
Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

9.1K
Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

169

Area of Science:

  • Orthopaedic research
  • Biomaterials science
  • Surgical innovation

Background:

  • Traditional bone grafts face limitations in clinical applications.
  • Synthetic bone cements offer potential alternatives for bone regeneration.
  • Osteopaste, a novel cement composed of tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP), has been developed.

Purpose of the Study:

  • To evaluate the radiographic density and new bone formation capacity of Osteopaste.
  • To compare Osteopaste's performance against JectOS (calcium phosphate) and MIIG-X3 (calcium sulfate) synthetic grafts.
  • To assess bone defect bridging in critical size defects over 24 weeks.

Main Methods:

  • A critical size defect was created in the proximal tibial metaphysis of subjects.
  • The defects were implanted with Osteopaste, JectOS, or MIIG-X3.
  • Radiographic density and new bone formation were assessed using plain radiographs and CT scans at 6, 12, and 24 weeks.

Main Results:

  • Osteopaste demonstrated radiographic density between JectOS (highest) and MIIG-X3.
  • New bone formation successfully bridged the critical size defect in the Osteopaste group by 12 weeks.
  • No bridging was observed in the JectOS or MIIG-X3 groups within the 24-week study period. Significant differences in mean density were noted (P<0.0001).

Conclusions:

  • Osteopaste effectively promotes new bone formation and bridges critical size defects.
  • Its performance in terms of density and bone formation is comparable to other synthetic grafts.
  • Osteopaste presents a viable alternative for bone grafting procedures in orthopaedics.