Related Experiment Video
Updated: Sep 10, 2025
10:28
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
12.8K
Bio-Active Composite Therapy (BACT) in Regenerative Orthopaedics.
Naveen Jeyaraman1,2,3, Madhan Jeyaraman1,2,3, Swaminathan Ramasubramanian2
1Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, 600077 Tamil Nadu India.
Indian Journal of Orthopaedics
|August 25, 2025
Summary
Bio-Active Composite Therapy (BACT) enhances bone and tissue regeneration using bioactive materials. While effective, challenges in biocompatibility and accessibility require further research for widespread clinical use.
Area of Science:
- Orthopaedic regenerative medicine
- Biomaterials science
- Tissue engineering
Background:
- Bio-Active Composite Therapy (BACT) integrates bioactive materials with biological systems for enhanced orthopaedic regeneration.
- It utilizes materials like hydroxyapatite, bioactive glasses, polymers, and metals to create scaffolds mimicking the extracellular matrix.
- These scaffolds support cellular activities crucial for bone and tissue repair.
Purpose of the Study:
- To systematically review the advancements in Bio-Active Composite Therapy for regenerative orthopaedics.
- To synthesize current knowledge on material types, fabrication techniques, and clinical applications of BACT.
- To identify challenges and future research directions in the field.
Main Methods:
- A systematic literature review was performed using PubMed, Scopus, Web of Science, and Google Scholar.
- Keywords included "Bio-Active Composite Therapy," "regenerative orthopaedics," and "bioactive materials" for studies from 2000-2024.
- Data extraction focused on materials, fabrication, applications, outcomes, and challenges, followed by thematic categorization.
Main Results:
- Hydroxyapatite and bioactive glasses are predominant materials due to their osteoconductive/osteoinductive properties.
- Additive manufacturing (3D printing) enables precise scaffold fabrication, enhancing cellular activity.
- BACT shows efficacy in bone, cartilage, and ligament repair, but biocompatibility and economic factors present challenges.
Conclusions:
- BACT offers transformative potential for musculoskeletal disorder treatments.
- Addressing biocompatibility, safety, and accessibility issues is key for clinical adoption.
- Future research should optimize materials and fabrication, supported by clinical trials for long-term validation.
