Related Experiment Video

Updated: Sep 10, 2025

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:02

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

178

Impact of Aortic Atherosclerosis on Clinical Outcomes After Transfemoral Transcatheter Aortic Valve Replacement

Yoshinori Shirai1, Akihito Tanaka1, Yoshiyuki Tokuda2

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|August 25, 2025
PubMed

Insights

Aortic atherothrombotic lesions are common in patients undergoing transfemoral TAVR. While short-term outcomes showed no significant impact, long-term mortality was numerically higher in patients with these lesions.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Vascular Surgery

Background:

  • Aortic atherothrombotic lesions pose risks of systemic embolization and adverse events during interventional procedures.
  • Understanding the impact of aortic atherosclerosis is crucial for patient management in TAVR.

Purpose of the Study:

  • To evaluate the association between the extent of aortic atherosclerosis and clinical outcomes following transfemoral transcatheter aortic valve replacement (TAVR).

Main Methods:

  • A single-center observational study included 278 patients undergoing transfemoral TAVR.
  • Preoperative computed tomography assessed aortic atherosclerosis, defining lesions as intimal thickening ≥4mm or mobile/ulcerated atheroma.
  • Patients were grouped based on the presence or absence of atherothrombotic lesions, with outcomes including mortality, stroke, embolism, and renal function monitored.

Main Results:

  • Atherothrombotic lesions were identified in 41.4% of patients; those with lesions had worse baseline renal function.
  • No significant short-term differences in all-cause death, stroke, systemic embolism, or worsening renal function were observed within 1 month.
  • Over a median 3-year follow-up, all-cause mortality was numerically higher in patients with atherothrombotic lesions.

Conclusions:

  • Atherothrombotic lesions are frequently detected in patients undergoing transfemoral TAVR.
  • Aortic atherosclerosis did not significantly affect short-term adverse outcomes post-TAVR.
  • A trend towards increased long-term mortality was noted in patients with atherothrombotic lesions.
Abstract

Keywords:
TAVITAVRadverse outcomesaortic atherosclerosisaortic atherothrombotic lesions

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