Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma CGRP Levels in Migraine: A Registry for Migraine Study.

Neurology·2026
Same author

Optic Tract Edema on MRI in Spontaneous Intracranial Hypotension with Sagging Brain.

AJNR. American journal of neuroradiology·2026
Same author

Magnetic resonance spectroscopy during migraine attacks: A systematic review.

Cephalalgia : an international journal of headache·2026
Same author

Migraine, headache disorders, and brain health: aligning advocacy with the UN Sustainable Development Goals.

The journal of headache and pain·2026
Same author

Migraine induced by vascular K<sub>ATP</sub> channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation.

Cephalalgia : an international journal of headache·2026
Same author

Molecular triggers of migraine aura: A systematic review of human pharmacological provocation studies.

Cephalalgia : an international journal of headache·2026

Related Experiment Video

Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K

Differences in cortical morphometry between persistent post-traumatic headache, migraine and healthy controls.

Rune Häckert Christensen1,2,3, Haidar Muhsen Al-Khazali1,2,3, Messoud Ashina1,3

  • 1Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Cephalalgia : an International Journal of Headache
|August 25, 2025
PubMed
Summary
This summary is machine-generated.

Persistent post-traumatic headache (PTH) shows enlarged brain regions in pain pathways, similar to migraine. These cortical changes may result from chronic pain signaling in persistent PTH.

Keywords:
cortical surface areacortical thicknesscortical volumemigrainepost-traumatic headache

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K

Related Experiment Videos

Last Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K

Area of Science:

  • Neurology
  • Neuroimaging
  • Neuroscience

Background:

  • Persistent post-traumatic headache (PTH) is a common and debilitating neurological condition.
  • It is often linked to mild traumatic brain injury and shares clinical similarities with migraine.
  • The specific brain changes associated with persistent PTH are not well understood.

Purpose of the Study:

  • To investigate cortical morphometric differences in individuals with persistent PTH compared to migraine patients and healthy controls.
  • To identify potential neurobiological substrates underlying persistent PTH.

Main Methods:

  • A cross-sectional study using 3T structural MRI.
  • Included 103 adults with persistent PTH, 296 with migraine, and 155 healthy controls.
  • Cortical surface area, thickness, and volume were analyzed using FreeSurfer with statistical corrections.

Main Results:

  • Participants with persistent PTH showed significantly larger surface area in the right anterior and posterior cingulate cortex compared to healthy controls.
  • Enlarged surface area was also observed in the right superior parietal cortex/postcentral gyrus in the PTH group versus controls.
  • No significant morphometric differences were found between persistent PTH and migraine groups.

Conclusions:

  • Persistent PTH is associated with distinct cortical morphometric alterations, particularly in pain-processing areas like the mid-cingulate and somatosensory cortex.
  • These findings suggest a potential shared neurobiological basis between persistent PTH and migraine.
  • The observed cortical enlargements may represent adaptive changes in response to sustained pain signals in persistent PTH.